Tamoxifen is a critical and inexpensive weapon in the fight against ER+ breast cancer.
Unfortunately tamoxifen therapy produces side effects that harm quality of life
and limit treatment compliance. Here we present 4 important findings:
- Mice respond to tamoxifen therapy in many of the same ways as humans, making
mice a valuable model for studying tamoxifen’s side effects.
- Tamoxifen treatment affects various hypothalamic cell types, most strikingly
neurons and ependymal cells.
- Loss of estrogen receptor-alpha reverses